Sildenafil from a drug class of phosphodiesterase 5 (PDE5) inhibitors, has become a first-line therapy for men with erectile dysfunction (ED). The efficacy of this medication was proven by a variety of clinical studies in men with ED of different etiology. The efficacy and safety clinical trials of Sildenafil in ‘general’ and diabetic men have shown that the medication significantly improves erectile dysfunction or impotence allowing men getting and keeping erections as long as needed.
Sildenafil is produced under the name Viagra and is approved to treat erectile dysfunction in men only. Sildenafil Canada under the name of Revatio is indicated to treat pulmonary arterial hypertension in men and women. The different medications containing Sildenafil should not be used together.
Sildenafil (Viagra) was the first oral PDE -5 inhibitor- medication for ED treatment approved by the FDA. Since the time of approval this medication became the top seller among other medications approved by the FDA. The reason why doctor and men choose this medication is in its high efficacy. Sildenafil inhibits PDE5, an enzyme that destroys cGMP (an enzyme responsible for muscle relaxation in the penis). By blocking the breakdown of cGMP by PDE5, Sildenafil stimulates the accumulation of cGMP in the penile tissues. The cGMP extends the smooth muscle relaxation in the corpus cavernosum of the male organ. It improves blood flow into the penis and enlarges the size of the penis – allows an erection. The blood becomes trapped within the penis and a person can keep his erection until the climax.